Clinical Inquiries
Clinical Inquiries
Does taking BP medicine at night (vs morning) result in fewer cardiovascular events?
EVIDENCE-BASED ANSWER: Probably not. In patients who have hypertension, the timing of administration of antihypertensive medications does not...
Clinical Inquiries
Does vaginal estrogen use increase the risk for adverse cardiovascular outcomes?
EVIDENCE-BASED ANSWER: NO. In general, nonoral estrogen use for menopausal symptoms is associated with a lower cardiovascular (CV) risk profile...
Clinical Inquiries
Are manual therapies effective at reducing chronic tension headache frequency in adults?
EVIDENCE-BASED ANSWER: MAYBE. Among patients with chronic tension headaches, manual therapies may reduce headache frequency more than sham manual...
Clinical Inquiries
Is low-dose naltrexone effective in chronic pain management?
EVIDENCE-BASED ANSWER: YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a...
Clinical Inquiries
Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D?
EVIDENCE-BASED REVIEW: NO. In adults with insulin-treated type 2 diabetes (T2D), continuous glucose monitoring (CGM) and flash glucose monitoring...
Clinical Inquiries
Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD?
EVIDENCE-BASED REVIEW: YES. In patients with known cardio- vascular disease (CVD), ezetimibe with a statin decreases major adverse cardiovascular...
Clinical Inquiries
Does hormone replacement therapy prevent cognitive decline in postmenopausal women?
EVIDENCE-BASED REVIEW: NO. Hormone replacement therapy (HRT) does not prevent cognitive decline in postmenopausal women—and in fact, it may...
Clinical Inquiries
Should RAAS blockade therapy be continued in patients with advanced renal disease?
EVIDENCE-BASED REVIEW: PROBABLY. Renin-angiotensin- aldosterone system (RAAS) blockade therapy should be continued in most patients with advanced...
Clinical Inquiries
Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35?
EVIDENCE-BASED REVIEW: Possibly. Elevated BMI is associated with an increased risk for stillbirth (strength of recommendation [SOR], B; cohort...
Clinical Inquiries
Does regular walking improve lipid levels in adults?
EVIDENCE-BASED ANSWER: Minimally. Regular moderate- intensity walking for a period of 4 or more weeks minimally decreased total cholesterol (TC)...
Clinical Inquiries
Does physical exercise reduce dementia-associated agitation?
EVIDENCE-BASED ANSWER: Not consistently. Physical exer- cise demonstrates inconsistent benefit for neuropsychiatric symptoms, including agitation...