Key clinical point: Patients with rheumatoid arthritis (RA) may be more susceptible to coronary atherosclerosis, and active intervention for RA may reduce the incidence of coronary atherosclerosis.
Major finding: Genetic predisposition to RA increased the risk for coronary atherosclerosis (odds ratio 1.0021; P < .05). However, genetic liability to coronary atherosclerosis did not increase the risk for RA (P = .06).
Study details: Findings are from a two-sample Mendelian randomization study that evaluated genetic variants associated with RA using the data of 14,361 patients and 42,923 control individuals and those associated with coronary atherosclerosis using data of 14,334 patients and 346,860 control individuals.
Disclosures: This study did not declare any specific source of funding. The authors declared no conflicts of interest.
Source: Nie Q et al. Rheumatoid arthritis and coronary atherosclerosis: A two-sample Mendelian randomization study. Front Cardiovasc Med. 2023;10:1033644 (Apr 28). Doi: 10.3389/fcvm.2023.1033644