Key clinical point: Preoperative elevated plasma D-dimer levels serve as an independent risk factor for poorer long-term survival outcomes in patients who have undergone curative surgery for gastric cancer.
Major finding: Multivariate analysis revealed elevated D-dimer levels to be independently associated with shorter overall survival (adjusted hazard ratio [aHR] 1.633; P = .003) and disease-free survival (aHR 1.58; P = .005).
Study details: Findings are from a retrospective study that included 903 patients with gastric cancer who underwent radical gastrectomy.
Disclosures: This study was sponsored by the National Natural Science Foundation of China, among others. The authors declared no conflicts of interest.
Source: Zhang X et al. D-dimer, a predictor of bad outcome in gastric cancer patients undergoing radical resection. Sci Rep. 2022;12:16432 (Sep 30). Doi: 10.1038/s41598-022-16582-9