Bleeding Disorders
From the Journals
Quercetin may reduce iron overload in beta-thalassemia major
Quercetin is part of the flavone family that exists mainly in apples, berries, onions, tea, and red wine.
From the Journals
Novel conditioning regimen shows benefit for beta-thalassemia major
The transplant regimen significantly reduced graft-versus-host disease following unrelated-donor hematopoietic stem cell transplant.
From the Journals
Two iron chelators better than one for thalassemia major
In a single-center study, deferasirox plus deferoxamine significantly decreased cardiac iron and serum ferritin, but deferasirox alone did not.
From the Journals
Hemophilia carriers face elevated risk of joint comorbidities
Individuals who carry hemophilia genes and have reduced clotting factor activity also have a higher risk of joint-related comorbidities.
Guidelines
ACOG advises bleeding disorder screening for teens with heavy menstruation
Bleeding disorders are found in approximately 20% of adolescent girls who present for evaluation of heavy menstrual bleeding and in 33% of...
Guidelines
New transfusion guidelines for thalassemia
Experts discussed recommendations for alpha and beta thalassemia as well as non–transfusion dependent thalassemia.
From the Journals
Lower BMD found in patients with severe hemophilia A
The decrease in BMD was correlated with reduced functional ability and body mass index, and vitamin D insufficiency or deficiency.
From the Journals
Hematuria is highly prevalent in pediatric hemophilia A and B
Hematuria was detected in nearly half of children with hemophilia during screening urinalysis.
From the Journals
Concomitant emicizumab, ITI shows promise in severe hemophilia A
A small case series of pediatric patients with hemophilia A demonstrates the feasibility of using immune tolerance induction for inhibitor...
From the Journals
Self-reported adherence fails to line up with objective measures in hemophilia
Social desirability bias may be playing a role in patients with hemophilia reporting better adherence than is measured through objective reports...
From the Journals
Review reveals lack of data on mild hemophilia A
A review of 17 studies showed limited and inconsistent data on bleeding, joint pain, quality of life, and other outcomes.