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Overall survival dips with vitamin D deficiency in melanoma
The research adds to existing evidence that “vitamin D levels can play an important and independent role in patients’ survival outcomes.”
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Finding HBV ‘cure’ may mean going ‘back to the drawing board’
Development of new HBV drugs looks more complicated than initially expected, and it’s time to refine and refocus goals, according to one...
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Statins in NAFLD: Taking a closer look at benefits
Statins could have multiple benefits in NAFLD, but there has been little insight into how they may be exerting such effects.
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Phase 3 data shows bulevirtide benefit in hepatitis D
“For us in the hepatitis D field, it is a really exciting time; it’s completely novel data and game-changing for patients.”
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Pemvidutide promising for fatty liver disease
Weight loss and multiple improvements in lipid parameters linked to nonalcoholic fatty liver disease were seen in a phase 1 trial.
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Novel liver-targeting drug offers hope for AAT deficiency
The investigational drug fazirsiran improved important liver parameters associated with alpha-1-antitrypsin deficiency.
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New onset-depression after RA diagnosis raises mortality risk ‘more than sixfold’
Developing depression after a diagnosis of rheumatoid arthritis substantially increased the risk for death over 10 years in a large Danish...
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Diagnostic axSpA MRI features differ in men and women
The cohort study of German patients with and without the disease found no major sex-specific differences for erosion and bone marrow edema but did...
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Deucravacitinib and orelabrutinib perform well in early lupus trials
Disease activity was reduced by treatment with either of the novel investigational agents in two separate early clinical trials, with further...
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Methotrexate enhances pegloticase response in uncontrolled gout
Greater efficacy and fewer infusion reactions seen with methotrexate-pegloticase combination than pegloticase alone in the placebo-controlled...
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Izokibep improves multiple psoriatic arthritis symptoms in phase 2 study
Greater percentages of patients treated with one of two doses of the novel IL-17 blocker achieved an ACR50 response versus placebo.
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Updated EULAR recommendations for AAV include new drugs, practices
Avacopan and mepolizumab feature in new European recommendations for managing antineutrophil cytoplasmic antibody–associated vasculitis.
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‘Shielding’ status provides best indicator of COVID-19 mortality in U.K. arthritis population
Shielding status was the highest ranked of all the risk factors identified for early mortality from COVID-19.
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Myositis guidelines aim to standardize adult and pediatric care
These are the first guidelines on how to manage adult and pediatric patients with idiopathic inflammatory myopathies (IIM).
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Reduced-frequency methotrexate monitoring causes no harm
Laboratory blood test results were similar despite moving from once every month to about once every 3 months or about once every 5 months during...