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Mesenteric adipose–derived stromal cell lactoferrin may mediate protective effects in Crohn’s disease
The cytokine profile from CD patient–derived mesenteric ADSCs and fat tissue was significantly different from that of their disease-free...
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Early results favor combo IL-15/anti-CD20 in indolent NHL
CHICAGO – The researchers tested the combination of rituximab with the IL-15 receptor super agonist complex ALT-803.
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Early results favorable for combo TLR9 agonist + pembro in advanced melanoma
CHICAGO – The combination of pembrolizumab with CMP-001 is being evaluated as a strategy to overcome resistance to PD-1 blockade for patients with...
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Nivolumab plus ipilimumab boosts PFS in advanced NSCLC with high tumor mutational burden
CHICAGO – In the first analysis from Checkmate 227, PFS was 7.2 months for the immunotherapy vs. 5.5 months for chemotherapy in patients with...
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OlympiAD: No statistically significant boost in OS with olaparib in HER2-negative mBC
CHICAGO – In the final analysis, median OS was 2.2 months longer for olaparib monotherapy versus physician’s choice of chemotherapy in patients...
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AGA Clinical Practice Update: Incorporating psychological care in the management of chronic digestive diseases
Previous studies have highlighted that the burden of chronic digestive diseases is amplified by psychosocial factors.
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Lower socioeconomic status linked with poor NSCLC prognosis in those with pretreatment weight loss
Socioeconomic status, as measured by insurance status, was significantly prognostic among patients with NSCLC and pretreatment weight loss, but...
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Bioengineered liver models screen drugs and study liver injury
Advances in bioengineered livers will show improving sensitivity for the prediction of clinically relevant drug and disease outcomes.
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Gaps exist in receipt of clinically indicated genetic counseling after breast cancer diagnosis
Less than half of patients diagnosed with early breast cancer with an indication for genetic risk evaluation received formal genetic counseling....
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Racial disparities by region persist despite multiple liver transplant allocation schemes
Disparities with African Americans have improved, but new disparities with Hispanics and Asians have developed.
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Engineered liver models to study human hepatotropic pathogens
2-D and 3-D cell cultures and humanized rodent models are be used and further developed.
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Objective response rate correlates poorly with overall survival in checkpoint-inhibitor trials
Six-month progression-free survival is recommended in place of objective response rate as an endpoint in future phase 2 checkpoint-inhibitor...
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NF-kappaB pathway could help solve resistance problem in mantle cell lymphoma
The research could set the stage for therapeutic targets to help avoid drug resistance in mantle cell treatment.
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Unscheduled visits for pain after hernia surgery common, costly
Postop pain after hernia surgery can mean numerous visits or calls to the surgical service.
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National Early Warning Score discriminates deterioration of inpatients with liver disease
Existing models estimate medium- and long-term prognosis in patients with liver disease, none are validated for short-term outcomes in inpatient...