Nephrology
From the Journals
Low-dose methotrexate carries higher risk for older patients with CKD
Adverse event data showed an increased risk of myelosuppression, sepsis, pneumotoxic effects, or hepatotoxic effects.
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Albuminuria reduction fuels finerenone’s kidney benefits
Mediation analyses of finerenone trial data show most of the drug’s kidney benefit and a third of its CVD benefit comes from cutting albuminuria...
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T2D: Real benefits of new oral antidiabetic drugs
What about in the real world? Could combining SGLT2 inhibitors with GLP-1R agonists be even more effective?
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CKD-EPI eGFR formula surpasses alternatives in young adults
The 2021 race-free CKD-EPI equation for estimating glomerular filtration rate outperformed two alternative formulas in adults aged 18-40 years.
Conference Coverage
Blood pressure lowering reduces dementia risk
“This proven, effective intervention should be widely scaled up to reduce the global burden of dementia.”
Conference Coverage
Obinutuzumab promotes renal preservation in lupus nephritis
A post hoc analysis of the NOBILITY trial showed improved outcomes for patients taking obinutuzumab (Gazyva), compared with placebo.
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Risk calculator for early-stage CKD may soon enter U.S. market
Klinrisk, which estimates an adult’s risk for CKD progression from 20 lab values, may spur more targeted, intensified treatment.
Conference Coverage
Aprocitentan reduces resistant hypertension in CKD
Aprocitentan, a novel dual endothelin antagonist, showed antihypertensive efficacy and manageable safety in people with chronic kidney disease.
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EMR prompt boosts albuminuria measurement in T2D
An EMR prompt in primary care to measure albuminuria and eGFR in adults with type 2 diabetes boosted screening by about 50%.
From the Journals
Piperacillin-tazobactam poses no renal risk in adults with sepsis
“These data should offer solace that if the choice is made to use piperacillin-tazobactam, there is not an increased risk of AKI.”
Conference Coverage
New calculator tool estimates fracture risk on dialysis
Calculator uses readily available clinical factors and will soon be freely accessible.