Translational Research
From the Journals
Transcription factor plays key role in AML gene regulatory networks
The findings could help in the development of targeted treatments for AML.
From the Journals
Aberrant RNA editing linked to aggressive myeloma
Hyper-editing of the multiple myeloma transcriptome leads to crippling of a key DNA-repair mechanism.
Conference Coverage
CDK8 inhibitor shows activity against AML
DUBROVNIK, CROATIA – SEL120 looks active against acute myeloid leukemia in preclinical work, but experts aren’t sure why.
From the Journals
Eltrombopag irons out kinks in hematopoiesis
The thrombopoietin-receptor agonist’s iron-chelating action stimulates hematopoietic stem cell activity, independent of the thrombopoietin...
Latest News
New hematologic, cardiovascular system link may have therapeutic implications
Early research sheds light on sex differences in thrombosis risk.
From the Editor
The enemy of good
By setting narrow limits on study eligibility, we risk treatment rationing through regulatory restriction.
News
FDA authorizes next-generation sequencing test for tumor profiling
MSK-IMPACT is a custom targeted sequencing platform that uses exon capture and sequencing to identify point mutations, small insertions and...
Conference Coverage
Gene editing aims to recreate beneficial mutation in SCD, beta-thalassemia
Production of fetal hemoglobin is protective against symptoms of these diseases.
From the Journals
Two SNPs linked to survival in R-CHOP–treated DLBCL
Use of a patient’s genetics rather than a tumor’s genetic makeup could change lymphoma treatment.
Found in Translation
Antibodies Part 3: In whose corner is genome editing’s best cut-man sitting?
We are in the midst of a revolution in genome editing. Science now exists in “AC,” or after CRISPR. Able to speedily and efficiently make genomic...
From the Journals
Researchers find ‘feedback loop’ key to reducing high blood pressure
Targeting the “feedback loop” between thrombin-driven factor XI and a receptor that helps thrombin propagate on platelets reduced both vascular...