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Methotrexate use justified for early RA, disease prevention
Rheumatoid arthritis prevention seems possible with intervention using a drug such as methotrexate for high-risk individuals.
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Rising arthritis prevalence driven by obesity
Population projections of arthritis prevalence are likely to be underestimated because the impact of BMI on joint disease is not fully understood...
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Pilot trial of first in kind biologic shows RA treatment potential
A phase IIb trial of the novel biologic mavrilimumab seems promising for RA patients who have failed to respond to biologics that target other...
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Hydroxychloroquine dosing guidelines have little impact in clinical practice
A substantial number of rheumatology patients are receiving excess starting and maintenance doses of hydroxychloroquine despite the existence of...
Article
Adolescent depression climbs, but is not matched by treatment
Major depressive episodes among adolescents are on the rise, but there hasn’t been a corresponding rise in treatment levels, suggesting many teens...
Article
Remission, low lupus activity predict lower risk of organ damage
Fulfilling definitions for prolonged disease remission and reaching Lupus Low Disease Activity State are both associated with a lower risk of...
Article
POEM procedure effective over the long term in achalasia
The therapeutic endoscopic procedure per-oral endoscopic myotomy (POEM) is safe and has a high clinical success rate at 2 years in patients with...
Article
PsA bone loss measurement: A surrogate for radiographic progression?
An advanced computer assisted digital x-ray radiogrammetry technique that measures bone thickness has the potential to be a surrogate marker of...
Article
Disease severity, QOL outcome measures need standardizing in atopic dermatitis research
The number of outcome measures used to assess disease severity and quality of life in atopic dermatitis studies has risen in recent years, but an...
Article
MS relapse predictors identified after patients stop treatment
Patients with multiple sclerosis treated with interferon-beta or glatiramer acetate who are aged 45 and over and have no evidence of clinical...
Article
Amyloid PET scans may have clinical utility in patients with cognitive impairment
Amyloid PET scans can affect diagnostic thinking and patient management when used alongside routine diagnostic work-up in adults suspected of...
Article
Two migraine prevention drugs prove no better than placebo in children
Amitriptyline and topiramate, commonly used to prevent migraine in adults, were associated with significantly more adverse events than was placebo...
Article
Anti–nerve growth factor drug has long-term OA pain benefit, but unclear safety
Treatment for a year with the human anti–nerve growth factor monoclonal antibody fulranumab provided pain relief and functional benefits to...
News
Younger age, inconsistency of care affect antiviral adherence in hepatitis B
Patients with chronic hepatitis B who are aged under 35 years or do not see the same clinician consistently are more likely to not take their...
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Deutetrabenazine modestly reduces chorea of Huntington disease
A deuterated form of the vesicular monoamine transporter type 2 inhibitor tetrabenazine appears to modestly reduce chorea of Huntington disease...